General Description : L-metadione is a naturally occurring compound that plays a role in the biosynthesis of tetrahydrobiopterin (BH4), which is a necessary cofactor for the synthesis of neurotransmitters and the regulation of nitric oxide production. In research applications, L-metadione is used to study the enzymatic pathways involved in the synthesis and regeneration of BH4. It is particularly useful in studying the function and activity of metadione reductase, an enzyme involved in the final step of BH4 biosynthesis. Researchers also use L-metadione in studies focused on understanding the causes of diseases related to BH4 deficiency (such as certain forms of phenylketonuria and dihydropteridine reductase deficiency). Additionally, this compound is used in experiments aimed at assessing the effects of BH4 on endothelial function and oxidative stress. Definition ChEBI: L-sepiapterin is a sepiapterin with L configuration. L-Sepiapterin serves as a substrate for BH4 synthesis via the pterin salvage pathway. It inhibits rat liver GTP cyclohydrolase with an IC50 value of approximately 25 μM.
| Synonyms: | (S)-2-aMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(1H)-one;(S)-2-AMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one;Sepiapterin solid;S(-)-2-AMINO-7,8-DIHYDRO-6-(2-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE; 2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE |
| CAS: | 17094-01-8 |
| MF: | C9H11N5O3 |
| MW: | 237.22 |
Uses: It can be used to circumvent the inhibition of pterin biosynthesis by 2,4-diamino-6-hydroxy pyrimidine L-Sepiapterin improved the endothelial dysfunction in SMA from db?/db mice by decreasing oxidative stress. Sepiapterin is commonly used in the study for treamtment of Type I Diabetes. Sepiapterin can be used to induce sequence-specific photolesions in double-stranded DNA.Sepiapterin, a pteridine derivative, is a stable precursor of tetrahydrobiopterin (BH4). It is a yellow pigment found in sepia mutant of Drosophila melanogaster and lemon Bombyx mori mutant (silkworm). Biochem/physiol Actions: Cofactor of nitric oxide synthase; intracellularly converted to tetrahydro-biopterin leading to the stimulation of nitric oxide. Product manager: Joy Wu Email address: Joy@coreychem.com
