Product Name:L-Hydroxyproline
CAS: 51-35-4
|
Appearance |
White crystals or crystalline Powder |
Conform |
|
Identification |
IR |
Conform |
|
Assay |
98.5~101% |
99.83% |
|
Transmittance |
≥95.0% |
99.2% |
|
Specific rotation[α]D25 |
-74.0°~-77° |
-75.2° |
|
PH |
5.0-6.5 |
5.84 |
|
Chloride(CI) |
≤0.02% |
0.02% |
|
Sulfate(SO4) |
≤0.02% |
<0.02% |
|
Ammonium salt |
≤0.02% |
<0.02% |
|
Ferric salt |
≤10ppm |
<10ppm |
Levamisole is the levo-isomer of the imidazothiazole class of compounds and is the primary source of its pharmacological activity. It was initially renowned for its exceptional anthelmintic properties and was later found to possess unique immunomodulatory functions. This dual mechanism of action allowed it to play a significant role in agriculture, veterinary, and human medicine over the past several decades. Understanding its multifaceted applications is crucial for a comprehensive appreciation of the compound’s value and risks.
2. Primary Applications
2.1 Veterinary Field: As a Broad-Spectrum Anthelmintic
The most fundamental and primary use of levamisole is as a highly effective anthelmintic in veterinary medicine.
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Mechanism of Action: It acts as an agonist of nicotinic acetylcholine receptors, causing persistent depolarization of the parasitic nervous system. This leads to spastic paralysis of the parasite’s muscles, resulting in its detachment from the host’s gastrointestinal tract and expulsion through feces.
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Targeted Parasites: Levamisole is highly active against a variety of nematodes, particularly gastrointestinal and pulmonary worms.
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Ruminants: Used to treat Ostertagia, Haemonchus contortus, Cooperia, etc., in cattle and sheep.
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Swine: Used to expel Ascaris suum (swine roundworm), Oesophagostomum, etc.
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Poultry: Can be used against Ascaridia galli (chicken roundworm) and Heterakis gallinarum.
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Administration: It can be administered via various routes, including oral (in drinking water or feed), injection, or topical application, making it convenient to use.
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