Hydroxypropyl methylcellulose phthalate

September 30, 2026

Hydroxypropyl methylcellulose phthalate (CAS No.: 9050-31-1): Product Profile, Parameter and Industrial Application Analysis

1. Product Overview

Hypromellose Phthalate (HPMCP, CAS:9050‑31‑1) is a pH‑sensitive cellulose‑derived pharmaceutical excipient widely applied in oral solid‑dosage formulation development and manufacturing.

Featuring phthalate‑modified side‑chains, it remains insoluble in gastric fluid and dissolves in intestinal fluid, performing enteric‑coating function for tablets, pellets and hard capsules. It can also be used as solid‑dispersion carrier, taste‑masking agent and granulation binder. Intended for pharmaceutical and nutraceutical formulation use only, it is not for injection. It plays a critical role in preparing acid‑resistant oral preparations for site‑specific intestinal drug release.

2、 Basic Product Information

1）Product Name: Hydroxypropyl methylcellulose phthalate
2）CAS NO.：9050-31-1
3）Molecular formula: C14H16N4

5）Structural formula:

6）Purity: ≥ 99%
7）Appearance: White solid
8）Product Manager Email:Cara@coreychem

3、 Frequently Asked Questions (FAQ)

1. Q: What will happen if HPMCP is stored under high humidity?

A: High humidity may trigger ester hydrolysis, weaken enteric performance..

2. Q: Can HPMCP be mixed with other excipients?

A: Yes, it is commonly combined with plasticizers such as triethyl citrate.

3. Q: What solvent is suitable for preparing HPMCP coating solution?

A: It dissolves in dichloromethane‑methanol mixed solvent; water‑dispersed system is also available.

4. Q: Does HPMCP comply with pharmacopoeia standards?

A: Yes, It meets requirements of ChP, USP.

5. Q: What is the shelf‑life of unopened HPMCP?

A: 24 months under recommended storage conditions.

4、 Application Cases

1. Enteric‑coated tablet：

Apply HP‑55 for enteric coating of acid‑sensitive active ingredients, protecting API from gastric acid degradation and releasing drug in the small intestine.

2. Fragile tablet coating：

Adopt HP‑55S for brittle tablets. High‑viscosity polymer provides tough film to prevent coating cracking during production and transportation.

3. Solid dispersion for poorly‑soluble drug：

Use HP‑50 as solid‑dispersion carrier to inhibit drug crystallization and improve dissolution rate for low‑solubility compounds.

4. Capsule enteric‑coating:

Apply HP‑55 for enteric coating of hard capsules, preventing capsule dissolution in stomach and achieving intestinal targeted release.

5. Taste‑masking granules:

Use HPMCP to coat bitter‑tasting drug particles, masking unpleasant taste and improving oral compliance for paediatric formulations..