Our group has been accomplished the first asymmetric total synthesis of gymnothelignan L in 14 steps. The synthetic approach features an anti Evans aldol reaction, a diastereoselective methylation, a Suzuki–Miyaura coupling and a bioinspired desymmetric transannular Friedel–Crafts reaction. Notably, the synthesis further demonstrated the biogenetic pathway that dibenzocyclooctene-type lignans are generated from eupomatilone-type lignans.
Gymnothelignan L is a rare lignan-type natural product isolated from Gymnotheca chinensis, featuring a unique multi-ring chiral structure and notable biological activities, including potential antioxidant, anti-inflammatory, and anticancer effects. Due to its structural complexity, it serves as both an important lead compound in drug discovery and an ideal target for challenging total synthesis and novel methodology development. We supply high-purity Gymnothelignan L and its structural derivatives, offering custom synthesis from milligram to multi-gram scale to accelerate your pharmacological research and innovative drug development.
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