FMoc-PNA-G(Bhoc)-OH CAS:186046-83-3_News

Introduction:
CAS 186046-83-3, widely known as Fmoc-PNA-G(Bhoc)-OH (or Fmoc-G(Bhoc)-Aeg-OH), is a specialized guanine-containing monomer. It serves as a critical building block for the solid-phase synthesis of Peptide Nucleic Acids (PNAs). 
PNAs are synthetic analogs of DNA and RNA that possess a unique peptide-like backbone, offering superior stability and binding affinity compared to natural nucleic acids. 
 It typically appears as a white to off-white powder, or as light yellow powder or cystalline.The compound is both air-sensitive and heat-sensitive. For long-term stability, it must be stored frozen at -20°C, preferably under an inert gas atmosphere. 
This article provides an overview of its chemical properties, structural features, key role in PNA synthesis, applications, and safe handling guidelines.

A Structural Deep Dive: The Architecture of a PNA Monomer:
The structure of FMoc-PNA-G(Bhoc)-OH is a sophisticated assembly designed for controlled, stepwise PNA synthesis. The molecule is built upon a peptide nucleic acid backbone, which is key to its function. 
PNAs are synthetic polymers that mimic the structure of DNA or RNA, but differ by having peptide-like backbone instead of sugar-phosphate backbone, which bind to complementary DNA and RNA sequences with high specificity and affinity.

The Importance of PNAs and Key Applications:
The significance of FMoc-PNA-G(Bhoc)-OH is directly linked to the utility of Peptide Nucleic Acids. PNAs are powerful tools in molecular biology and therapeutic development due to their remarkable stability against enzymatic degradation 
and their high binding affinity for DNA and RNA targets. This monomer is thus an essential building block for synthesizing a wide array of PNA-based tools.

Key applications include:
--Antisense Oligonucleotide Development: PNAs are used to create antisense agents that can bind to specific mRNA sequences, blocking gene expression. 
This makes them valuable tools in cancer research and for developing novel therapeutic strategies.
--Gene Delivery Systems: PNA-based systems facilitate the delivery of genetic material into cells, enhancing gene therapy applications.
--Diagnostic Tools: PNAs are incorporated into highly specific biosensors and diagnostic assays for detecting unique nucleic acid sequences associated with pathogens or genetic mutations, enabling early disease diagnosis.
--Molecular Biology Research: PNAs are extensively used to study fundamental processes such as protein-nucleic acid interactions, and they serve as molecular probes for various genomic investigations

Conclusion:
CAS 186046-83-3, the Fmoc-PNA-G(Bhoc)-OH guanine monomer, is a cornerstone of modern PNA chemistry. Its sophisticated design, featuring a peptide-like backbone and orthogonal Fmoc/Bhoc protecting groups.
This makes it an indispensable tool for synthesizing high-affinity, nuclease-resistant nucleic acid analogs. By enabling the construction of targeted PNAs, this compound is driving innovation in antisense therapeutics, gene therapy, molecular diagnostics.
This product is a peptide nucleic acid (PNA) and can be useful in the detection of circulating microRNA biomarkers from body fluids with application to prostate cancer diagnosis. 
It is useful for efficacy of peptide nucleic acid and selected conjugates against specific cellular pathologies of amyotrophic lateral sclerosis. 
Also useful for SNP discrimination by tolane-modified peptide nucleic acids and detection of drug resistance in pathogens.
    Product manager: Joy Wu                                                 Email address: Joy@coreychem.com