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ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate CAS No.: 308831-93-8

May 13, 2026

ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate CAS No.: 308831-93-8 is a thiophene organic compound primarily used as an impurity reference standard in the quality control process of the drug Relugolix.

Product Mananger: grace@coreychem.com

📋Basic information:

  • Chemical name: ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate
  • CAS No.: 308831-93-8
  • Molecular Formula: C17H18N2O6S
  • Molecular Weight: 230.26

📌Specification:

Appearance: Light yellow powder
Purity: ≥99%
Density :  1.338±0.06 g/cm3
Package: 1KG/Bag, 25kg/Drum;or as per customer request
Storage: Store in cool & dry place.
 

🧩Application of ethyl 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate CAS No.: 308831-93-8

1. Reference Standard for Pharmaceutical Impurities

As a specific impurity (Impurity 53) of Relugolix, it is applied for quality control, qualitative and quantitative analysis of impurities, as well as analytical method development and validation of this drug. Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist, clinically used for the treatment of prostate cancer, uterine fibroids and other diseases.

2. Pharmaceutical Intermediate

Used for the synthesis of drug molecular building blocks containing thiophene ring, nitrophenyl and carbamate structures, and applied to the preparation of GnRH receptor antagonists, antitumor drugs, anti-inflammatory drugs and other heterocyclic drugs.

3. Organic Synthetic Building Block

It contains derivatizable ester group, amino protecting group (ethoxycarbonyl) and nitro group. It can construct complex thiophene derivatives through hydrolysis, deprotection, reduction, coupling and other reactions, and is used for new drug R&D and research on organic synthetic methodology.

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