DSPE-PDP(cas no: 144735-79-5)
DSPE-PDP is a functional phospholipid-PEG conjugate used to stabilize lipid nanoparticles and provide a reducible disulfide linkage for thiol-containing molecules, enabling reversible conjugation for targeted and functionalized drug delivery systems.
| Product Name | DSPE-PDP |
| Synonyms | DSPE-PDP;1,2-distearoyl-sn-glycero-3-phosphoethanolamine–N-[3-(2-pyridyldithio)propionate](sodiumsalt);1,2-distearoyl-sn-glycero-3-phosphoethanolamine–N-[3-(2-pyridyldithio)propionate](sodiumsalt)(DSPE-PDP);Octadecanoicacid,1-[3-hydroxy-3-oxido-8-oxo-10-(2-pyridinyldithio)-2,4-dioxa-7-aza-3-phosphadec-1-yl]-1,2-ethanediylester,(R)-(9CI);DSPE-SPDP;DSPE-PDP(SodiumSalt)FolicacidPEGDSPE |
| CAS NO | 144735-79-5 |
| Purity | 98% above |
| Appearance | White Powder |
| MF | C49H89N2O9PS2 |
| MW | 945.34 |
| Contact | selina@coreychem.com |
Key Functions
1. Stabilization of lipid nanocarriers
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DSPE anchors the molecule into lipid bilayers of liposomes, LNPs, or micelles.
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PEG provides a steric hydration layer that improves particle stability, dispersity, and in vivo circulation.
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Widely applied in nucleic acid therapeutics, protein delivery, and vaccine systems.
2. Reducible disulfide–thiol conjugation (core advantage)
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The PDP group contains an active disulfide bond that reacts with thiol groups (–SH) under mild conditions.
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Compatible with:
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Cysteine-containing peptides (e.g., RGD, CPP)
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Thiolated antibodies or antibody fragments
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Thiol-modified proteins, sugars, or small molecules
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Features:
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High selectivity and mild reaction conditions
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Reversible linkage that can release the conjugated molecule in reductive environments (e.g., intracellular)
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3. Construction of targeted and functionalized delivery systems
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Enables targeted liposomes or LNPs
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Supports:
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Tumor- or cell-specific targeting
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Controlled intracellular release
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Fluorescent or imaging labeling
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Conjugation of proteins, peptides, or drugs
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4. PEGylation effect
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PEG forms a hydrated layer on the particle surface
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Reduces plasma protein adsorption and immune clearance
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Extends circulation time and improves bioavailability
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Enhances biocompatibility for in vivo applications
| Functional DSPE‑PEG Analogues and CAS Numbers | ||
| Product Name | Function / Application | CAS Number |
| DSPE‑PEG‑Maleimide (e.g., DSPE‑PEG2000‑Maleimide) | Terminal Maleimide group allows selective conjugation with thiol (‑SH) containing molecules, used for targeted or functionalized nanocarriers. | 474922‑22‑0 |
| DSPE‑PEG‑NH₂ (DSPE‑PEG‑Amine) | Terminal amine (‑NH₂) can react with activated carboxyl/NHS ester groups, used for conjugating proteins, peptides, antibodies, etc. | 474922‑26‑4 |
| DSPE‑PEG‑COOH (DSPE‑PEG‑Carboxylic acid) | Terminal carboxyl (‑COOH) can be activated via EDC/NHS chemistry to conjugate amine-containing ligands. | 1403744‑37‑5 |
| DSPE‑PEG‑Azide (DSPE‑PEG‑N₃) | Terminal azide group allows Click chemistry (e.g., conjugation with alkyne-containing ligands). | 1938081‑39‑0 |
| DSPE‑PEG‑Biotin (DSPE‑PEG‑Biotinyl) | Terminal biotin enables labeling or capture via the biotin‑streptavidin system. | 385437‑57‑0 |
Contact us for more information: selina@coreychem.com
