📌Basic Information
| Product name | Domperidone |
| Synonym | kw-5338;midazol-1-yl)propyl)-4-piperidinyl)-;Domperidone,Motilium |
| CAS NO. | 57808-66-9 |
| Appearance | White solid |
| Content | ≥99.0% |
| MF | C22H24ClN5O2 |
| MW | 425.91 |
| Related Categories | Digestive system medications; Drugs; Antiemetic and emetic drugs; Medical raw materials |
| Transport Information | Non-dangerous goods |
| HS Code | 2933990099 |
| Application | Commonly used drugs for promoting gastric motility and antiemetics |
| Packaging | 25kg/drum；1000kg/drum |
| Contact Info | lucy@coreychem.com |
✨ Information
Chinese name: Domperidone
English name: Domperidone
CAS number: 57808-66-9
Molecular formula: C₂₂H₂₄ClN₅O₂
Molecular weight: 425.91 g/mol
Structural category: Benzimidazole derivatives
Original manufacturer: Janssen Company from Belgium (trade name: Metoclopramide/Motilium)
🔍Physical and chemical properties
Appearance: White or off-white crystalline powder
Melting point: 241-243℃ (decomposes)
Solubility: DMSO 8-40 mg/mL (soluble); Ethanol 1 mg/mL (slightly soluble); Water: insoluble
Density: ~1.3 g/cm³
Dry weight loss: ≤0.5%
💊Pharmacological action
Domperidone is a peripheral dopamine D2 receptor antagonist and has the following characteristics:
Gastric motility promoting effect: Acts directly on the gastrointestinal wall, increases the tension of the lower esophageal sphincter, prevents gastroesophageal reflux, enhances gastric peristalsis, promotes gastric emptying, and coordinates the movements of the stomach and the duodenum.
Antiemetic effect: Inhibits nausea and vomiting, effectively preventing bile reflux
Difficult to cross the blood-brain barrier: It has no inhibitory effect on dopamine receptors in the brain, thus causing no adverse neurological or mental reactions such as extrapyramidal symptoms.
Prolactin release: It can stimulate the secretion of prolactin.
🎯Clinical applications
Functional, organic, infectious nausea and vomiting
Non-ulcer dyspepsia
Indigestion, heartburn, upper abdominal pain
Gastric dyskinesia (delayed gastric emptying)
📧 Contact Info
lucy@coreychem.com
