| Product name | Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium (II) |
| Synonym | Bis{bis(tert-butyl)[4-(dimethylamino)phenyl]phosphine}palladium(II)chloride; Dichlorobis{[4-(N,N-dimethylamino)phenyl]di-t-butylphosphino}palladium(II) |
| CAS NO. | 887919-35-9 |
| Appearance | Yellow powder |
| Purity | 98% Min |
| MF | C32H56Cl2N2P2Pd |
| MW | 708.07 |
| Structural formula |  |
| Related categories | Precious metal catalyst |
| Transport Information | Non-hazardous goods |
| HS Code | 28439000 |
| Product Manager Email | sophia@coreychem.com |
Bis(di-tert-butyl(4-dimethylaminophenyl)phosphine)dichloropalladium(II) is a highly efficient palladium catalyst for the Suzuki-Miyaura coupling reaction. Its core application is highly specific: serving as a crucial catalyst for the efficient construction of carbon-carbon bonds in pharmaceutical chemistry research and production.
Its primary applications and characteristics can be summarized as follows:
🔬 Core Application: Synthesis of Biologically Active Pharmaceutical Molecules
The key value of this catalyst lies in the efficient synthesis of structurally complex drug molecules, where it plays a critical role, particularly in the synthesis of antitumor drugs.
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Key Application Example: It is an indispensable component in the process route for synthesizing the antitumor drug Savolitinib. Savolitinib is a highly selective c-Met inhibitor used to treat diseases such as non-small cell lung cancer. This catalyst is responsible for precisely connecting key molecular fragments during its synthesis.
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Other Drug Syntheses: Beyond Savolitinib, this type of high-performance catalyst is also commonly used in the laboratory research and process development of other complex heterocyclic molecules, such as anticancer drugs, antidepressants, and anti-infective agents.
⚙️ Performance Advantages: Why is it Chosen?
Among numerous palladium catalysts, it is specifically chosen for the following properties:
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High Activity and Selectivity: The phosphine ligand featuring bulky tert-butyl and dimethylamino functional groups stabilizes the palladium center, facilitates the reaction progression, and exhibits good tolerance towards sensitive functional groups, minimizing side reactions.
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Suitable for Complex Late-Stage Functionalization: Its excellent performance enables the final coupling step on complex drug molecules (or advanced intermediates) containing various sensitive functional groups, which is crucial for improving synthetic efficiency.
In summary, this product is a specialty catalyst designed for high-performance Suzuki coupling reactions, primarily serving the synthesis and process development of advanced pharmaceutical molecules (especially Savolitinib).
Contact information:
Contact: Sophia Li
Email: sophia@coreychem.com
