Product Name:Ampicillin sodium
CAS: 69-52-3
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Appearance |
White or off-white powder or crystalline powder, odorless or slightly odorous |
Conform |
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Identification |
In the chromatogram recorded under the content determination section, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution. |
Conform |
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The infrared absorption spectrum of the test sample should be consistent with the reference spectrum of ampicillin trihydrate. |
Conform |
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The reaction for identifying sodium salts |
Conform |
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Alkalinity |
PH 8.0~10.0 |
9.6 |
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Clarity and color of the solution |
≤1 turbidity standard solution |
<0.5 turbidity standard solution |
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≤5 yellow-green standard colorimetric solution |
<YG2 standard colorimetric solution |
Antibacterial Spectrum and Clinical Applicability
The “broad-spectrum” characteristic of ampicillin sodium is its greatest clinical advantage. It not only retains the potent activity of penicillin against most Gram-positive cocci (such as Streptococcus hemolyticus and Streptococcus pneumoniae), but also expands coverage to include certain Gram-negative bacilli, including Haemophilus influenzae, Escherichia coli, and Proteus mirabilis, among others. It is also the first-line or preferred drug for the treatment of infections caused by Enterococcus and Listeria species. Based on these properties, it is widely used in clinical practice to treat respiratory tract infections, urinary tract infections, gastrointestinal infections, meningitis, and septicemia. Of note, ampicillin sodium is ineffective against methicillin-resistant Staphylococcus aureus (MRSA) that produces penicillinase, which reveals the first major limitation of its application.
Judy@coreychem.com
