Amentoflavone

📌Basic Information

✨Basic Information

Amentoflavone, also commonly known as Amentoflavone, has the CAS number 1617-53-4. Its molecular formula is C₃₀H₁₈O₁₀, and its molecular weight is 538.46 g/mol.

This product is a yellow solid powder and is a natural biflavone compound formed by the oxidative coupling of two apigenin molecules. Its chemical structure is 3′,8”-biapigenin. It is primarily derived from plants such as Selaginella tamariscina, Selaginella pulvinata, and Ginkgo biloba leaves.

🎯Physical and Chemical Properties

The main physical properties of Taxifolin are as follows:

Appearance: Yellow powder

Melting point: Above 300°C

Boiling point: Approximately 910.5°C (760 mmHg)

Density: Approximately 1.7 g/cm³

Flash point: Approximately 308.5°C

Vapor Pressure: 0.0 ± 0.3 mmHg (25°C)

Refractive Index: Approximately 1.793

Solubility: Sparingly soluble in water; soluble in DMSO. Solubility in DMSO ranges from 34 to 125 mg/mL

Stability: Prone to oxidation; must be stored away from light

🔍Major Biological Activities

Taxifolin is a natural product with multiple biological activities, the main ones being:

Anti-inflammatory Effects: It inhibits NF-κB activation and downregulates COX-2 and iNOS expression, thereby suppressing PGE2 biosynthesis. In RAW 264.7 cells, it concentration-dependently inhibits nitric oxide production at concentrations ranging from 1 to 60 µM.

Antioxidant Effects: It exhibits excellent antioxidant properties, scavenging free radicals and reducing oxidative stress.

Antitumor activity: It exhibits inhibitory effects on human glioma cells (U-87 MG), with an IC₅₀ of 100 µM at 48 hours. It induces apoptosis and arrests the cell cycle at the sub-G1 phase. In SW480 cells, high concentrations (150 μmol/L) significantly induce apoptosis.

Neuroprotective effects: As a negative modulator of GABA(A) receptors, it exerts neuroprotective effects in epileptic mouse models through anti-inflammatory mechanisms. Oral administration of 25 mg/kg (once daily for 3 consecutive days) effectively prevents seizures.

Antibacterial activity: It exhibits inhibitory activity against various pathogenic bacteria, including Enterococcus faecalis, Staphylococcus aureus, Streptococcus mutans, Escherichia coli, and Pseudomonas aeruginosa, with MIC values ranging from 4 to 32 µg/mL.

Antiviral activity: It exhibits antiviral activity.

Enzyme inhibitory activity: It is a potent inhibitor of CYP3A4 and CYP2C9 and may interact with various drugs. It is also an inhibitor of human tissue plasminogen activator (tPA).

📦Storage and Stability

Storage Conditions: The recommended storage temperature is -20°C, with a shelf life of at least one year. The solid powder can be stored for at least one month at 4°C. Some suppliers also recommend long-term storage at 2–8°C.

Precautions: This compound is prone to oxidation and must be stored in a sealed container, protected from light and moisture. Prolonged exposure to air will result in a decrease in concentration. If dissolved in a solvent other than DMSO, it is recommended to aliquot the solution and store it at -80°C.

📚Safety Information
Hazard Classification: Flammable in solid form; irritating to the skin, eyes, and respiratory system.

GHS Statement: Contact with strong oxidizing agents may cause combustion.

Handling Precautions: This product may be toxic to humans. Wear a lab coat and disposable gloves during handling to avoid direct skin contact or inhalation.

Ecological Impact: May be harmful to the environment; special attention should be given to water bodies. Biodegradable.

Transport Information: May be transported under normal temperature conditions; not classified as dangerous goods.

📧 Contact Info

lucy@coreychem.com