Product name: 6-Bromo-4-methoxy-1H-indazole
Cas No.: 885519-21-1
Advantage spot goods, inventory products, contact us to get more information: selina@coreychem.com
6-Bromo-4-methoxy-1H-indazole (CAS: 885519-21-1) is a bromo-substituted indazole heterocycle widely used as an important intermediate in chemical and pharmaceutical research. Below is a detailed overview of its functions and applications:
1. Chemical Uses
-
Pharmaceutical Intermediate
-
This compound is commonly used in the optimization of new drug molecules, especially in the design of kinase inhibitors, anticancer drugs, anti-inflammatory agents, and CNS-active compounds.
-
The indazole ring is a key scaffold in many drugs, such as:
-
Indazole-based tyrosine kinase inhibitors (e.g., Vemurafenib, Tivantinib)
-
PDE inhibitors (used in cardiovascular or antidepressant research)
-
-
The 6-bromo substitution provides an active site for further functionalization, suitable for coupling reactions such as Suzuki, Sonogashira, and Buchwald–Hartwig to generate various derivatives.
-
-
Organic Synthesis Reagent
-
Serves as an intermediate for heterocyclic substitution reactions in the synthesis of complex molecules, materials chemistry, and polymer studies.
-
The bromine atom’s reactivity allows it to act as a substrate in cross-coupling reactions, enabling the introduction of new aryl or alkyl groups.
-
2. Role in Research and Drug Discovery
-
Used in lead compound discovery to construct small-molecule libraries.
-
Important for Structure–Activity Relationship (SAR) studies to analyze electronic and steric effects.
-
Some reported derivatives show potential biological activities such as:
-
Antitumor effects (by inhibiting BRAF, PI3K, etc.)
-
Anti-inflammatory activity
-
CNS modulation properties
-
3. Applications in Materials and Optoelectronics (Secondary Use)
-
Indazole derivatives have applications in OLED emitting materials and organic semiconductors, due to their conjugated structure and stability.
-
The bromo-substituted structure facilitates coupling reactions to build extended π-conjugated systems.
Summary
| Category | Main Application |
|---|---|
| Pharmaceutical Chemistry | Intermediate for kinase inhibitors, anticancer and anti-inflammatory agents |
| Organic Synthesis | Substrate for coupling reactions, heterocyclic scaffold builder |
| Research Use | SAR studies, small-molecule library component |
| Materials Science | Potential monomer for OLEDs and organic electronics |
Why choose us?
1. Proven Expertise in This Product
We have been continuously producing and optimizing this product for years. Our manufacturing process is mature and stable, and the product has been successfully exported to multiple countries, earning consistent recognition from our customers.
2.Strong R&D and Custom Synthesis Capability
With our own laboratory and experienced R&D team, we specialize in custom synthesis and scale-up services, particularly in molecular building blocks, advanced pharmaceutical intermediates, and dye intermediates. We can develop tailor-made products based on your required chemical structure.
3.Comprehensive After-Sales Support
We provide full after-sales service. If you encounter any issues after receiving the goods, please feel free to contact us — we will respond promptly and ensure the problem is resolved to your satisfaction.
Contact our product manager to get more information: selina@coreychem.com
