Description and Basic Properties: 5-Deazaflavin (CAS 26908-38-3) is a synthetic, aromatic heterocyclic compound structurally related to natural flavins, such as vitamin B2 (riboflavin). Its molecular formula is C₁₁H₇N₃O₂, with a molecular weight of approximately 213.19 g/mol. The IUPAC name for this compound is pyrimido[4,5-b]quinoline-2,4(1H,3H)-dione, and it has a calculated density of 1.434 g/cm³ and a refractive index of 1.688.The defining structural feature of 5-Deazaflavin is its unique chemical modification. It is generated by substituting the aza group (containing a nitrogen (N) element) at the 5-position of the flavin backbone with a deaza group (containing a carbon (C) element). This seemingly small change in its core ring system dramatically alters its redox potential, giving it a more negative reduction potential compared to natural flavins, which allows it to participate in a wider range of biochemical reactions. This modified structure enables 5-deazaflavin to function in a manner similar to NAD+ (Nicotinamide Adenine Dinucleotide), a crucial coenzyme in the vitamin B3 family, while retaining the chemical stability of a vitamin B2 backbone.
Characterization and Mechanism of Action: Unlike natural flavins or other coenzymes, 5-Deazaflavin acts directly as a coenzyme without needing to be converted into another active form, such as NAD+. This direct mechanism makes it significantly more potent than some well-known molecules. Scientific comparisons indicate that 5-deazaflavin is 40 to 100 times stronger than Nicotinamide Mononucleotide (NMN), a popular compound in anti-aging research.Its mechanism of action is central to its impressive biological activity. 5-Deazaflavin is known to play an important role in the NAD+ biosynthetic pathway. By promoting the body's production of NAD+, it helps regulate metabolism, maintain energy balance, repair DNA, and reduce oxidative stress at the cellular level. Because NAD+ levels naturally decline with age, this pathway is critically linked to the aging process and overall cellular health.Furthermore, 5-Deazaflavin possesses redox activity and has been demonstrated to function as a photocatalyst in biological redox systems.
Primary Applications and Advantages: 5-Deazaflavin's unique properties translate into a wide array of high-value applications, spanning from scientific research to the nutraceutical industry. In biochemical and academic research, it is a valuable tool in enzymology and electron transfer studies, acting as a reference standard in flavoprotein research and analytical method development. Its unique redox activity also makes it an ideal photocatalyst for investigating biological redox systems.However, the most commercially significant and widely discussed applications of 5-Deazaflavin are in the health and supplement industries. --Potent Anti-Aging Agent: Its ability to boost NAD+ production, combined with its high potency, makes it a promising candidate for next-generation anti-aging supplements. It helps activate mitochondria and sirtuin genes, which play a crucial role in cellular metabolism and longevity. --Powerful Antioxidant: 5-Deazaflavin effectively neutralizes free radicals, helping to protect cells from oxidative damage, thereby slowing the aging process and reducing the risk of chronic diseases. --High Safety and Stability: It has been shown to be safe for human consumption and possesses excellent chemical stability, which is a significant advantage over other compounds, offering a longer shelf life for manufacturers and consumers.
Future Prospects: The future for 5-Deazaflavin (CAS 26908-38-3) appears exceptionally bright. Its potential to surpass the efficacy of current market-leading compounds like NMN has already captured the attention of the nutraceutical industry. As the global population continues to focus on health, longevity, and preventative medicine, the demand for more effective, stable, and safe anti-aging ingredients is expected to surge. In the long term, its unique chemical structure and properties position it for development in new drugs and therapies for various age-related diseases. Its role in DNA and RNA synthesis also hints at applications in precision medicine and genetic research. Product manager: Joy Wu Contact/Email address: Joy@coreychem.com
