5-Acetyl-1,3-dimethylbarbituric Acid (DAB) — The “Precision Scalpel” for Selective Primary Amine Protection
In organic synthesis, when a molecule contains both primary and secondary amines, how do you protect only the primary amine without affecting the secondary one? This long-standing challenge is elegantly solved by 5-Acetyl-1,3-dimethylbarbituric acid, commonly known as DAB — it selectively forms enamine adducts with primary amines under mild conditions, with near-quantitative yields and friendly deprotection protocols. A true “gem” in amino protection strategy.
Product Specifications
| Property | Value |
|---|---|
| CAS Number | 58713-03-4 |
| Molecular Formula | C₈H₁₀N₂O₄ |
| Molecular Weight | 198.18 |
| Appearance | White to light yellow powder or crystalline |
| Melting Point | 99°C |
| Density | 1.327 g/cm³ |
| Boiling Point | 305.7°C (760 mmHg) |
| Flash Point | 135.9°C |
| LogP | −0.88 |
| PSA | 74.76 |
| Storage | Room temperature (recommended cool & dark, <15°C) |
| HS Code | 2933540000 |
Applications
🎯 Selective Primary Amine Protection — DAB’s Core Value
🧬 Polyamine Chemistry — Selective Spermidine Derivative Synthesis
🧪 Aminosugar Protection
🔗 Amino Linker Protection
🏗️ Barbituric Acid Derivative Building Block
We offer high-purity (S)-3-hydroxytetrahydrofuran with the following features:
- Purity ≥ 98%
- Comprehensive quality control system ensuring excellent batch-to-batch consistency
- Flexible supply from gram to kilogram scale
- Custom packaging and special specifications available upon request
- Complete technical documentation provided (COA, MSDS, etc.)
- Sample Requests Now Open Complimentary small samples are available for evaluation, along with COA and analytical data.
- Spectroscopic data available: ¹H NMR, ¹³C NMR, MS, IR
For custom deuterated compound synthesis or scale-up inquiries, please do not hesitate to reach out.
More details, just contact: Nicole@coreychem.com
