4,4′-Dihydroxybiphenyl-3,3′-dicarboxylic acid (Dobpdc) is used as the ligand to obtained a novel porous nanomaterial – Metal‑Organic Frameworks (MOFs), via solvothermal reaction with metal ions followed by a single‑crystal‑to‑single‑crystal transformation.
Basic information:
Product Name: 4,4′-Dihydroxybiphenyl-3,3′-dicarboxylic acid (Dobpdc)
CAS: 13987-45-6
MF: C14H10O6
MW: 274.23
Specification:
Appearance White to off-white Solid
Purity: >99%
Storage temp.: Room temperature
Product Mananger: grace@coreychem.com
4,4′-Dihydroxybiphenyl-3,3′-dicarboxylic acid, abbreviated as Dobpdc, is an organic molecule with dual hydroxyl (-OH) and carboxyl (-COOH) functional groups on its biphenyl backbone. This unique structure endows it with versatile applications across materials science, pharmaceutical synthesis, and environmental engineering. Its most prominent use lying in metal-organic framework (MOF) fabrication.
This is the primary and most well-established application of Dobpdc.
- It acts as a bridging ligand to coordinate with various metal cations , (such as Fe²⁺/Fe³⁺, Mg²⁺, Zn²⁺) , to form porous MOF materials, with the representative one being Fe₂(dobpdc).
- MOFs constructed from Dobpdc feature ultra-large pore volumes, tunable pore sizes, and strong affinity for polar gas molecules. They are widely used in carbon dioxide capture and separation (e.g., capturing CO₂ from flue gas in power plants or industrial exhaust to mitigate greenhouse gas emissions), as well as selective adsorption of other gases (such as separating methane from natural gas mixtures or storing hydrogen for clean energy systems).
- Additionally, these MOFs can serve as heterogeneous catalysts. For instance, Fe₂(dobpdc) exhibits high catalytic activity and selectivity in the oxidation of cyclohexane to cyclohexanol/cyclohexanone, and can also catalyze organic coupling reactions with its metal active sites and ligand functional groups.
The dual hydroxyl and carboxyl groups in Dobpdc are reactive sites for organic transformations, making it a valuable intermediate in fine chemical synthesis:
- It can be used to synthesize 4-hydroxypyridine derivatives, 2-aminopyridine, 2-aminopyrimidine and other nitrogen-containing heterocyclic compounds, which are core building blocks for developing targeted drugs, antibacterial agents, and cardiovascular drugs.
- Its carboxyl groups can undergo esterification, amidation reactions, while hydroxyl groups can be subjected to alkylation or acylation, enabling the preparation of modified organic molecules with specific biological activities for preclinical drug research.
