Contact Manager: Emma Song Email Address: emma@coreychem.com
Product Overview
4-Cyano-7-azaindole (CAS 344327-11-3), formally named 1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile, is a high-value bicyclic heterocyclic intermediate widely utilized in medicinal chemistry and organic synthesis.
Its fused pyrrole-pyridine ring and reactive cyano group deliver excellent structural stability and chemical modifiability, making it a key building block for novel small-molecule drug development.
As a reliable global supplier, we offer high-purity 4-Cyano-7-azaindole with consistent batch quality, rigorous quality control and customizable packaging for pharmaceutical R&D and industrial-scale production.
Basic Chemical Specifications
Our 4-Cyano-7-azaindole strictly follows international industrial standards with standardized technical parameters, fully adaptable to laboratory research and industrial synthesis:
| Product Name: | 4-CYANO-7-AZAINDOLE |
| Synonyms: | 4-CYANO-7-AZAINDOLE;1H-PYRROLO[2,3-B]PYRIDINE-4-CARBONITRILE;4-Cyano-7-azaindole 97%;4-Cyano-1H-pyrrolo[2,3-b]pyridine;7-Azaindole-4-carbonitrile;1H-Pyrrolo[2,3-b]pyridine-4-carbonitrile(9CI);4-CYANO-7-AZAINDOLE ISO 9001：2015 REACH;SWF-42 |
| CAS: | 344327-11-3 |
| MF: | C8H5N3 |
| MW: | 143.15 |
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Purity: ≥97% (HPLC tested)
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Appearance: Off-white to pale yellow solid powder
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SMILES: N#Cc1ccnc2[nH]ccc12
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MDL Number: MFCD08272235
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Storage Condition: Sealed, cool and dry environment, away from direct sunlight and high temperature
Core Product Advantages
Compared with common azaindole derivatives, 4-Cyano-7-azaindole features unique structural and synthetic advantages, supporting high-efficiency innovative drug research:
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Superior Biological & Chemical Activity: The combination of 7-azaindole skeleton and cyano group provides strong biological target affinity and chemical reactivity. The rigid bicyclic structure enhances molecular binding performance, while the cyano group enables flexible downstream derivatization.
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Excellent Synthetic Versatility: It is compatible with mainstream organic reactions including cross-coupling, nucleophilic substitution and reduction. It can be efficiently modified to construct complex heterocyclic frameworks, enriching candidate drug compound libraries.
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Reliable Batch Consistency: Manufactured under standardized compliant processes, each batch is verified via HPLC and MS testing to guarantee high purity, low impurities and stable quality, eliminating disturbances to experiments and production.
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High Druggability Value: It optimizes the structural defects of traditional intermediates, effectively improving the metabolic stability, target selectivity and overall druggability of synthesized compounds.
Main Applications
As an indispensable heterocyclic intermediate, 4-Cyano-7-azaindole is widely applied in high-end pharmaceutical R&D, organic synthesis and biochemical research:
1. Innovative Drug R&D
It serves as a core precursor for JAK inhibitor synthesis, a key class of targeted drugs for autoimmune diseases and myeloproliferative disorders. Its specific ring structure ensures high target binding selectivity for safer, more effective targeted therapies. It is also extensively used in anti-tumor, anti-inflammatory and neurological drug development.
2. Organic Synthesis & Chemical Intermediate
As a versatile building block, it is widely used to construct complex heterocyclic molecules. It is an essential raw material for fine chemical production, agrochemical development and advanced new material synthesis.
3. Biochemical Research
It acts as a critical tool compound for biochemical mechanism research, including enzyme interaction analysis and molecular binding studies, supporting global academic and pharmaceutical frontier research.
