4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline is a pharmaceutical intermediate mainly used for the synthesis of anticancer drug Tucatinib, which plays a key role in targeted therapy.
Product Mananger: grace@coreychem.com
Basic information:
- Chemical name: 4-([1,2,4]Triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline
- Product Name: Tucatinib intermediate
- CAS: 937263-71-3
- Molecular Formula: C13H12N4O
- Molecular Weight: 240.26
Specification:
Appearance: White to off-white powder
Purity: 98%min
Storage: Keep sealed, keep in cool and dry place, avoid light.
- Key Intermediate for Tucatinib: Tucatinib is a highly selective HER2 tyrosine kinase inhibitor. It treats HER2-positive breast cancer, especially in patients with brain metastases. This intermediate provides the triazolopyridine-oxy-aniline pharmacophore fragment in synthesis. It serves as the core structural unit linking the quinazoline parent nucleus and side chains. It directly affects the drug’s activity and selectivity.
- Applications in Other Pharmaceutical R&D: Compounds with a triazolopyridine skeleton often work in screening new drugs targeting kinase inhibitors (such as JAK and EGFR), anticancer agents and anti-inflammatory drugs. This intermediate can act as a starting material for lead compound optimization. It supports structure-activity relationship studies and derivative synthesis.
- Organic Synthesis Building Block: It helps synthesize heterocyclic compounds with a triazolopyridine-aniline structure. It can produce various substituted derivatives. It applies to molecular design in agrochemical and material chemistry fields.
