| Product name | (3S,4E)-3-Hydroxy-7-[(triphenylmethyl)thio]-4-heptenoic acid |
| Synonym | (S,E)-3-hydroxy-7-(tritylthio)hept-4-enoicacid; 4-Heptenoicacid,3-hydroxy-7-[(triphenylMethyl)thio]-,(3S,4E)-; (3S,4E)-3-Hydroxy-7-[(triphenylMethyl)thio]-4-heptenoic; (3S)-3-hydroxy-7-tritylsulfanylhept-4-enoicacid; (E,3S)-3-hydroxy-7-tritylsulfanyl-hept-4-enoicacid; (3S,4E)-3-Hydroxy-7-(tritylsulfanyl)-4-heptenoicacid; (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoicacid |
| CAS NO. | 180973-24-4 |
| Appearance | White to off-white powder or crystalline powder |
| Purity | 98% Min |
| MF | C26H26O3S |
| MW | 418.55 |
| Structural formula | ![(3S,4E) 3 hydroxy 7 [(triphenylmethyl)thio] 4 heptenic acid cas no 180973 24 4](https://www.coreychem.com/wp-content/uploads/2026/04/3S4E-3-hydroxy-7-triphenylmethylthio-4-heptenic-acid-cas-no-180973-24-4.gif) |
| Related categories | pharmaceutical intermediates |
| Transport Information | Not dangerous goods |
| HS Code | 2930909090 |
| Product Manager Email | sophia@coreychem.com |
Product Applications
1. Core Application:
Key Intermediate for the Synthesis of HDAC Inhibitors
This compound is mainly used as a key chiral building block for the total synthesis of bioactive macrolide histone deacetylase (HDAC) inhibitors, especially Thailandepsin B, a potent and selective HDAC inhibitor with potential antitumor activity.
The (S)-hydroxyl and carboxyl groups serve as key reactive sites for intramolecular macrolactonization.
The (S)-chiral center determines the correct stereochemical configuration of the final product.
The (E)-double bond provides conformational rigidity to facilitate cyclization.
The triphenylmethylthio group acts as an acid-labile protecting group for the sulfhydryl group (-SH), which can be selectively removed in later synthetic stages to release the active sulfhydryl group. .
2. Other Applications
Chiral Synthesis Research:
Used as a precursor for complex chiral molecules in the development of novel chiral drugs and natural product analogs.
Organic Synthetic Methodology:
Applied in the study of selective functional group transformations of β-hydroxycarboxylic acids, protecting group strategies, and novel macrolactonization reactions.
3. Usage Restrictions
For research use only; not for human or veterinary clinical applications.
Serves as a synthetic intermediate and is not directly used as a drug.
Contact information:
Contact: Sophia Li
Email: sophia@coreychem.com
