Chinese Name: 3,5-二氟苯腈
English Name: 3,5-Difluorobenzonitrile
CAS: 64248-63-1
We are very proud to recommend one of our core products—3,5-Difluorobenzonitrile. With its unique molecular structure (featuring symmetrically substituted fluorine atoms at the 3 and 5 positions of the benzene ring and a highly reactive cyano group), 3,5-Difluorobenzonitrile has become an indispensable key building block and intermediate in the fields of pharmaceuticals, agrochemicals, materials science, and fine chemical synthesis. It is particularly suitable for applications requiring the introduction of fluorine-containing groups and cyano groups to modulate the physicochemical properties and biological activity of target molecules.
1. Product Core Highlights and Unique Value
Significant Electronic Effects and Multifunctional Reactive Sites:
The two key functional groups in its molecular structure—the symmetrically substituted fluorine atoms and the cyano group—constitute its core competitive advantages.
Properties of Fluorine Atoms:
The fluorine atoms at the 3 and 5 positions exhibit strong electron-withdrawing effects and unique stereoelectronic properties. They can significantly modulate the electron cloud density of the benzene ring, enhance the reactivity of adjacent sites, and improve the metabolic stability, lipophilicity, and membrane permeability of the final molecule.
Reactivity of the Cyano Group:
The cyano group serves as an excellent reactive handle, participating in various transformations such as hydrolysis to carboxylic acid or amide, reduction to aminomethyl, addition with nucleophiles, or acting as a starting material for constructing heterocycles (e.g., triazoles, tetrazoles).
This structural combination enables 3,5-Difluorobenzonitrile to:
① Efficiently serve as a key building block for synthesizing structurally complex, activity-optimized fluorinated pharmaceutical molecules and agrochemicals.
② Precisely modulate the physicochemical properties (such as pKa, dipole moment, stability) of target molecules through the introduction of fluorine atoms.
③ Provide a fluorinated aromatic structural unit for the research and development of novel functional materials (e.g., liquid crystal materials, polymer monomers).
2. Wide Range of Application Scenarios
① Pharmaceutical Intermediates: Widely used in the synthesis of various fluorinated active pharmaceutical ingredients (APIs), especially in areas like anticancer drugs, antidepressants, and anti-infective agents, where the introduction of fluorine is crucial for enhancing efficacy and improving pharmacokinetic properties.
② Agrochemical Intermediates: Used in the creation of novel fluorinated insecticides, herbicides, and fungicides. Fluorine atoms often enhance the biological activity, selectivity, and environmental stability of pesticides.
③ Materials Science: Used as a monomer or building block for synthesizing fluorinated polymers, liquid crystal materials, and other high-performance specialty materials. Fluorine atoms can impart excellent chemical stability, heat resistance, and surface properties to materials.
④ Fine Chemical Synthesis: Serves as a versatile building block for synthesizing more complex fluorinated aromatic compounds, such as 3,5-difluorobenzoic acid, 3,5-difluorobenzylamine, etc., meeting diverse R&D needs.
3. The Core Advantages of Our Products
① High Purity Guarantee: Strict production and purification processes ensure the product meets high purity standards (typically ≥98%, by GC/HPLC), satisfying the stringent requirements of pharmaceutical R&D and fine synthesis for raw materials.
② Excellent Batch-to-Batch Consistency: A comprehensive quality control system ensures highly consistent and reproducible product performance across different batches.
③ Reliable Supply Capacity: As one of our strategic advantage products, we possess mature synthesis technology and large-scale production capacity, enabling us to provide you with long-term, stable, and sufficient supply guarantees, eliminating your concerns.
④ Professional Customization and Service: We can offer flexible support according to specific customer needs (such as special specifications, custom packaging) and have a strong technical team to provide you with professional consultation and solutions related to product applications.
4.Why Choose Our 3,5-Difluorobenzonitrile?
When selecting fluorinated aromatic building blocks, the precision of the molecular structure, accessibility of reactive sites, and product purity are often key to project success. 3,5-Difluorobenzonitrile represents an ideal balance for symmetrically difluorinated benzonitrile compounds—it provides the beneficial physicochemical property modulation brought by fluorine atoms while retaining the high flexibility of the cyano group as a multifunctional reactive handle.
Whether you are developing a new generation of pharmaceutical or agrochemical active molecules, creating high-performance fluorinated materials, or conducting cutting-edge organic synthesis methodology research, high-purity, high-quality 3,5-Difluorobenzonitrile will be a solid foundation for your R&D success.
Contact our sales and technical team now to learn about the detailed specifications, pricing information for 3,5-Difluorobenzonitrile (CAS: 64248-63-1), and how we can help your project break through bottlenecks and create value!
Contact Information:
Contact: Sophia Li
Email: sophia@coreychem.com
