3-nitro-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide is key intermediate of ABT 199, which is now have been mass produced.
Basic Information
【Product name】 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
【 Molecular Weight 】 315.35
【CAS】[1235865-75-4 ]
【Physical Properties】White to off-white solid powder, Assay≥97%，total impurities≤2.5%
Product Manager: Grace Zhang/grace@coreychem.com
A1: ABT-199 (Venetoclax) is an experimental B-cell lymphoma 2 (BCL-2) inhibitor jointly developed by AbbVie and Roche.
A2: It is a small-molecule inhibitor targeting the BCL-2 protein, widely applied in the treatment of hematologic malignancies such as chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). ABT-199 selectively inhibits the BCL-2 protein, blocking its anti-apoptotic function and thereby inducing programmed cell death in cancer cells.
A3: ABT-199 is designed to selectively inhibit the function of the BCL-2 protein, restore the cell’s communication system, and induce cancer cells to self-destruct, thereby achieving the effect of treating tumors.
A4: The chemical name of the ABT-199 intermediate is 3-nitro-4-[(tetrahydro-2H-pyran-4-yl)methylamino]benzenesulfonamide.
A5: It is a key intermediate for the synthesis of ABT-199. This intermediate provides the core skeleton within the drug’s molecular structure, ensuring the high efficiency and targeting specificity of the final product.
A6: The ABT-199 intermediate (3-nitro-4-[(tetrahydro-2H-pyran-4-yl)methylamino]benzenesulfonamide) is a reagent used in the synthesis of BTK, PI3K, and JAK-2 inhibitors, and also serves as a pharmaceutical intermediate. The high purity and stability of this intermediate are crucial for the synthesis pathway of ABT-199. Its quality directly affects the activity, safety, and pharmacokinetic properties of the final drug, and therefore it must strictly comply with pharmaceutical-grade standards.
Other intermediates for ABT199:
CAS: 1228780-72-0 1-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazine
CAS: 1228779-96-1 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
CAS: 1228837-05-5 4′-chloro-5,5-dimethyl-3,4,5 ,6-tetrahydro-[1,1′-biphenyl]- 2-carbaldehyde
CAS: 183208-36-8 5-methoxy-1H-pyrrolo[2,3-b]x pyridine
CAS: 1235865-76-5 methyl 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoate
CAS: 98549-88-3 1H-pyrrolo[2,3-b]pyridin-5-ol
For any questions or more details, feel free to contact me at grace@coreychem.com.
