3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid(DFPA) is a high-purity fluorinated pyrazole carboxylic acid intermediate, appearing as white to off-white crystalline powder. It features excellent stability and reactivity, widely serving as a key building block for agrochemicals and pharmaceuticals.
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📋Basic information:
- Chemical name: 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (DFPA)
- CAS: 176969-34-9
- Molecular Formula: C6H6F2N2O2
- Molecular Weight: 176.12
📌Specification:
| Appearance: | White to off-white powder |
| Purity: | ≥99% |
| Melting point: | 201-203°C |
| Density : | 1.52 |
| Solubility: | Slightly soluble in water, easily soluble in polar organic solvents such as methanol, acetonitrile, DMSO etc |
| Package: | 25KG/Bag |
| Storage: | Store at room temperature, Store in a sealed, well-ventilated container. Keep away from light, |
🧩Application of 3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid CAS No.: 176969-34-9
1. Agricultural Sector: Key Intermediate for SDHI Fungicides (Dominant Use)
This compound is a core raw material in the synthesis of succinate dehydrogenase inhibitor (SDHI) fungicides. The difluoromethyl group and pyrazole heterocycle it contains are key structural moieties that impart high biological activity to these fungicides.
Derived Fungicide Varieties: It can be used to synthesize several highly effective, broad-spectrum fungicides, including fluxapyroxad, isopyrazam, benzovindiflupyr, and sedaxane.
Application Scenarios: These fungicides are widely applied to crops such as wheat, corn, rice, soybeans, fruits, and vegetables. They effectively control various fungal diseases, including rust, powdery mildew, leaf spot, and gray mold, offering both protective and curative effects with high crop safety.
2. Pharmaceutical Sector: Intermediate for Fluorinated Drug Synthesis
As a fluorinated pyrazole carboxylic acid intermediate, this compound is used in the design and modification of drug molecules. Key application areas include:
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Synthesis of pharmaceutical intermediates for anti-inflammatory, antibacterial, antimalarial, and antitumor agents.
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Leveraging the unique physicochemical properties of fluorine atoms (enhancing lipophilicity, metabolic stability, and bioavailability) to optimize drug efficacy and pharmacokinetic profiles.
3. Other Sectors
Materials Sector: Used as a monomer or modifier in the preparation of corrosion-resistant fluorinated materials, high-end electronic chemicals, and functional polymers.
Organic Synthesis Sector: Participates in various fine chemical syntheses via reactions such as esterification and amidation, serving as an important building block for constructing fluorinated pyrazole structures in organic synthesis.
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