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2,2-Dimethylthiopropionamide

September 21, 2026

2,2-Dimethylthiopropionamide (CAS No.: 630-22-8): Product Profile, Parameter and Industrial Application Analysis

1. Product Overview

2,2,2‑Trimethylthioacetamide (CAS:630‑22‑8) is a valuable sulfur‑containing building‑block widely used in organic synthesis and pharmaceutical research.

Featuring a thioamide moiety, it undergoes Hantzsch cyclization to form thiazole skeletons for various cyclization and condensation reactions. It is intended solely for laboratory‑scale research and intermediate synthesis, rather than finished API or pharmaceutical products. It plays a critical role in preparing sulfur‑bearing bio‑active heterocyclic molecules, including key intermediates for Dabrafenib.

2、 Basic Product Information

1）Product Name: 2,2,2‑Trimethylthioacetamide
2）CAS NO.：630‑22‑8
3）Molecular formula: C5H11NS

5）Structural formula:

630 22 8

6）Purity: ≥ 99%
7）Appearance: White solid
8）Product Manager Email:Cara@coreychem

3、 Frequently Asked Questions (FAQ)

1. Q: What functional group dominates its chemical reactivity?

A: Thioamide group.

2. Q: What toxic gas may be generated under heat or acid?

A: Hydrogen sulfide.

3. Q: What storage environment does this product require?

A: Sealed, cool‑dry place, away from heat and strong acid.

4. Q: Can it be directly formulated into pharmaceutical preparations?

A: No, it is only a research‑grade intermediate.

5. Q: Which classic reaction is it mainly involved in?

A: Hantzsch thiazole cyclization reaction. Hantzsch

4、 Application Cases

1. Thiazole‑skeleton construction：

Key raw material for Hantzsch cyclization reaction to build thiazole heterocyclic structures.

2. Synthesis of Dabrafenib‑related pharmaceutical intermediates：

Precursor for preparing key intermediates of anti‑tumor molecule Dabrafenib at lab scale.

3. Preparation of sulfur‑containing heterocyclic derivatives：

Used to produce various thiazole and thiazoline derivatives for drug‑molecule research.

4. Sulfur‑donor building‑block for organic synthetic methodology:

Serves as sulfur‑containing building‑block for laboratory cyclization and condensation research.

5. Synthesis of pharmaceutical lead compounds:

Applied by CROs and university labs for assembling sulfur‑bearing bio‑active lead molecules.

5、 Safety and Storage

Keep container tightly sealed. Store in cool, dry and well‑ventilated place at 2‑8°C. Keep away from strong acid, heat and oxidants.

6、Product Manager Information

Product Manager: Cara Lee
Email: cara@coreychem.com

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