1. Product Overview
2-Mercaptonaphtho[1,2-d]thiazole is a high-value fused heterocyclic intermediate. Featuring a large conjugated naphthothiazole skeleton and active thiol group, it exhibits excellent lipophilicity and chemical reactivity. It is widely used in pharmaceutical intermediate synthesis, fluorescent probe development, metal corrosion inhibitors and fine chemical library preparation, serving as a critical fused-ring building block in organic and material chemistry.
2. Basic Product Information
1）Product Name: 2-Mercaptonaphtho[1,2-d]thiazole
2）CAS NO.：4845-64-1
3）Molecular Formula: C₁₁H₇NS₂
4）Molecular Weight: 217.31
5）Structural Feature: 
6）Purity: ≥98.5%
7）Appearance: White to yellow-brown crystalline powder
8）Melting Point: 254 °C
9）Density: 1.46 g/cm³ (25 °C)
10）Solubility: Insoluble in water, soluble in DMF, DMSO and hot ethanol
11）Flash Point: 204.0 °C
12）Product Manager Email: emma@coreychem.com
3. Frequently Asked Questions (FAQ)
1). What are its core advantages over common mercaptobenzothiazole?
It owns a larger conjugated fused-ring structure, with better lipophilicity and photophysical properties. It is mainly applied in high-end fine chemistry and biomedical research, different from ordinary benzothiazole used for rubber additives.
2). What is the optimal laboratory synthesis route?
The mainstream route adopts 1-naphthylamine as raw material, through thermal cyclization reaction with sulfur reagents. It features stable yield and simple operation, suitable for laboratory small-batch preparation.
3). How to purify the product efficiently?
Mixed solvent recrystallization is the preferred method to obtain high-purity products. Column chromatography is not recommended due to strong silica gel adsorption causing product loss.
4). What reaction limitations should be noted?
The active thiol group is sensitive to strong oxidants and strong alkalis. Oxidation easily produces disulfide impurities, so neutral and mild reaction conditions are required.
5). Is this product available for direct industrial application?
It is a professional synthetic intermediate, not a final industrial additive or drug API. It needs structural modification to prepare target functional derivatives.
4. Application Cases
Overview: This product relies on unique fused conjugated structure and reactive thiol groups, widely applied in drug synthesis, functional materials, analytical detection and agrochemical research.
1). Antibacterial and Antitumor Pharmaceutical Intermediates
Its high-lipophilic fused ring improves cell permeability. It can be modified to synthesize naphthothiazole derivatives, used for anti-bacterial and anti-tumor active molecule screening.
2). Fluorescent Probe Precursor Materials
With excellent conjugated photophysical properties, it can be derived into metal ion fluorescent probes, applied for environmental detection and biochemical analysis.
3). Organic Metal Corrosion Inhibitors
The N and S multi-coordination sites can adsorb on metal surfaces. Its derivatives are ideal corrosion inhibitors for alloy and industrial circulating water systems.
4). Fused Heterocyclic Compound Library Construction
It is a core building block for rapidly constructing naphthothiazole compound libraries, supporting high-throughput biological activity screening.
5). Agrochemical Lead Compound Research
It can be used to synthesize S-substituted derivatives for fungicidal and insecticidal activity evaluation, providing new candidates for pesticide development.
5. Safety and Storage
1）Keep containers tightly sealed and store in cool, dry and ventilated places.
2）Avoid light exposure and high temperature to prevent oxidation and deterioration.
3）Store separately from strong oxidants and strong alkalis.
4）Wear protective gloves and goggles during operation, avoid dust inhalation.
5）Long-term storage temperature is recommended below 15 °C.
6. Product Manager Information
6. Product Manager Information
Product Manager: Emma Song
Email: emma@coreychem.com
