2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione (CAS: 835616-61-0)
Purity:>95% |
Packaging information: 5g; 10g; 1kg;10kg; >10kg bulk cargo
Customization accepted, audit accepted
1. What this compound is?
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione is mainly a research chemical / building block, not a drug.
It is also known as 5-fluorothalidomide, a structural analog of thalidomide.
Commercial suppliers describe it as a white to pale yellow solid with purity typically >98%, and it requires careful storage under inert gas.
Safety data indicate it has significant toxicity and potential reproductive toxicity, so proper PPE is required.
2. What this compound is used for?
Its primary function is in PROTAC (Proteolysis Targeting Chimera) research.
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It serves as a cereblon (CRBN) ligand, which is an E3 ubiquitin ligase commonly used in PROTAC designs.
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In a PROTAC molecule, one end binds the target protein and the other end binds CRBN; this induces ubiquitination and subsequent degradation of the target protein.
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The “5-fluoro” modification provides a useful attachment point for linkers without significantly affecting CRBN binding.
Therefore, this compound is mainly used as a precursor / building block to synthesize CRBN-based PROTAC degraders.
For example, it has been used as the CRBN ligand in PROTACs designed to degrade proteins such as IRAK4.
3. Summary
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Main function: A research-use building block for designing CRBN-based PROTAC degraders.
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Not a therapeutic drug: It is not used clinically.
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Safety considerations: Toxic and potentially harmful to fertility/fetal development; handle with caution.
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