(1S,5R,6S)-Ethyl 5-(pentan-3-yl-oxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylate

Oseltamivir key intermediate: 5- (pentan-3-yloxy) -7-oxo-bicyclo [4.1.0] hept-3-en-3-carboxylic acid ethyl ester (CAS: 204254-96-6)

Product Overview

Chinese name: Ethyl 5- (pentane-3-yloxy) -7-oxo-bicyclo [4.1.0] hept-3-en-3-carboxylate
English name: (1S, 5R, 6S) – Ethylene 5- (pentan-3-yl-oxy) -7-oxa-bicyclo [4.1.0] hept-3-ene-3-carboxylate
CAS number: 204254-96-6
Molecular formula: C ₁₄ H ₂₂ O ₄
Molecular weight: 254.32
EINECS number: 606-550-3

Structural formula:

This product is a core key intermediate for the synthesis of Oseltamivir Phosphate (trade name Tamiflu/Tamiflu) and occupies an important position in the anti influenza drug industry chain.

Product Manager Email:ada@coreychem.com

Physical and chemical properties

Parameter values
Appearance: White to off white crystalline powder
Density: 1.1 ± 0.1 g/cm ³
Boiling point: 336.5 ± 42.0 ° C (760 mmHg)
Flash point: 145.1 ± 27.9 ° C
Melting point: 56-57 ° C
Refractive index: 1.492
LogP: 3.47
Steam pressure: 0.0 ± 0.7 mmHg (25 ° C)

Core application: Key intermediate for the synthesis of oseltamivir

Pharmaceutical intermediates
This product is the core epoxy intermediate in the synthesis route of oseltamivir phosphate. Oseltamivir, as a neuraminidase inhibitor, is globally recognized as a first-line drug for the treatment and prevention of influenza A and B.

In the synthesis process of oseltamivir, this compound provides key reaction sites for introducing necessary functional groups for subsequent ring opening reactions through its unique epoxy ring structure. Its high purity and stereochemical purity directly determine the quality and efficacy of the final API (active pharmaceutical ingredient).

Research on Standards and Impurities
In addition to industrial synthesis, this compound can also be used as an impurity standard for oseltamivir drugs for:

Development and validation of analytical methods

Drug Quality Control (QC)

Research on Impurities in Generic Drug (ANDA) Declaration

CATO and other standard suppliers provide high-purity specifications (>95%) of the compound, along with complete structural compliance reports for nuclear magnetic resonance, mass spectrometry, liquid phase, and gas phase, which can meet the quality traceability requirements under the ISO17034 system.

Storage and transportation conditions

To ensure product stability, it is recommended to follow the following conditions:

Storage temperature: 2 ° C~8 ° C (refrigerated storage)

Environmental requirements: cool, dry, dark, sealed storage

Packaging specifications: can be customized according to customer needs (1g/bottle, 5g/bottle, 1kg, 25kg, etc.)

Mode of transportation: high-density ice bags and thick wall foam boxes are used to ensure good properties under low temperature conditions

Application field

Application Direction Description
The core raw material for the synthesis of anti influenza drugs using Oseltamivir API
Pharmaceutical intermediate trade for pharmaceutical enterprises to carry out subsequent process production
Drug impurity standards are used for drug quality research and analysis testing
Organic synthesis research and development utilizes epoxy structures for complex molecular construction

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Product Manager Email:ada@coreychem.com