1H-Pyrrolo[2,3-b]pyridin-5-ol (5-Hydroxy-7-azaindole) CAS No.: 98549-88-3 is a 7-azaindole heterocyclic compound primarily used as a key intermediate in the synthesis of Venetoclax, and also serves as an impurity reference standard (Venetoclax Impurity 12) in the quality control process of the drug Venetoclax.
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📋Basic information:
- Chemical name: 1H-Pyrrolo[2,3-b]pyridin-5-ol (5-Hydroxy-7-azaindole)
- CAS No.: 98549-88-3
- Molecular Formula: C7H6N2O
- Molecular Weight: 134.14
📌Specification:
| Appearance: | Light yellow to light brown powder |
| Purity: | ≥99% |
| Melting Point: | 219–220 °C |
| Density : | 1.41±0.1 g/cm3 |
| Package: | 1KG/Bag, 25kg/Drum；or as per customer request |
| Storage: | Keep in dark place, sealed in dry, room temperature. |
🧩Application of 1H-Pyrrolo[2,3-b]pyridin-5-ol (5-Hydroxy-7-azaindole) CAS No.: 98549-88-3
1. Key Intermediate for Venetoclax (BCL-2 Inhibitor)
2. Pharmaceutical Impurity Reference Standard
As an associated impurity (Venetoclax Impurity 12) in the Venetoclax synthetic route, it is applied for impurity profiling, qualitative and quantitative analysis of impurities, analytical method development and validation, and quality control release testing of Venetoclax API and finished drug products.
3. VEGFR-2 Inhibitor Synthesis
1H-Pyrrolo[2,3-b]pyridin-5-ol is also used as a synthetic building block in the development of potent VEGFR-2 (vascular endothelial growth factor receptor 2) inhibitors, which are a class of targeted anticancer agents for anti-angiogenesis therapy. The 7-azaindole scaffold containing a modifiable hydroxyl group enables the construction of diverse kinase inhibitor libraries for anticancer drug R&D.
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