📰 1,4-Dimethoxy-2,3-Dibromobenzene: A Versatile Dibromo Aromatic Intermediate for Organic Synthesis and Advanced Materials

Published: August 14, 2026

Category: Organic Chemistry & Advanced Materials Research

1,4-Dimethoxy-2,3-Dibromobenzene (CAS 5030-61-5), also known as 2,3-Dibromo-1,4-dimethoxybenzene and 1,4-二甲氧基-2,3-二溴苯, is a highly functionalized aromatic compound with the molecular formula C8H8Br2O2 and molecular weight 295.96 g/mol. The compound features two bromine atoms and two methoxy groups on a benzene ring, providing a useful combination of reactive and electronically modulating substituents.

The two adjacent bromine substituents make 1,4-Dimethoxy-2,3-Dibromobenzene a valuable starting material for further aromatic functionalization and organic synthesis. Its structure has also been reported in synthetic literature and is associated with routes involving functionalized aromatic intermediates.

With applications centered on organic synthesis and research into functional aromatic compounds, this intermediate is suitable for pharmaceutical chemistry, specialty chemical development, and advanced molecular material research.

🌟 Unique Chemical Properties

1,4-Dimethoxy-2,3-Dibromobenzene possesses several structural characteristics that make it useful as an aromatic synthesis intermediate:

🧬 Dibromo Functionalization – Two bromine atoms provide reactive positions for further aromatic transformation and molecular construction.

⚗️ Methoxy-Substituted Aromatic Structure – The two methoxy groups influence the electronic properties of the aromatic ring and provide a defined functionalized scaffold.

🔬 Versatile Synthetic Intermediate – Its combination of bromine and methoxy substituents makes it suitable for further chemical modification.

🌡️ Defined Physical Properties – Reported commercial data include a melting point around 154–158°C and an appearance described as a white to off-white solid.

💡 Research-Oriented Building Block – Suitable for laboratories and industrial R&D teams developing functional aromatic compounds and advanced intermediates.

🔬 Research & Industrial Applications

⚗️ Organic Synthesis and Aromatic Functionalization

1,4-Dimethoxy-2,3-Dibromobenzene is primarily valuable as a functionalized aromatic intermediate. The brominated positions provide opportunities for further transformations, enabling researchers to construct more complex aromatic molecular frameworks.

Research applications include:

• Functional aromatic compound synthesis
• Multi-step organic synthesis
• Aromatic substitution and transformation
• Specialty intermediate development
• Molecular structure modification

The defined substitution pattern provides a useful starting point for researchers seeking to introduce additional functionality into an aromatic scaffold.

🔗 Cross-Coupling & Molecular Construction Research

Aryl bromides are widely used as reactive handles in transition-metal-catalyzed cross-coupling chemistry. The two bromine substituents in 1,4-Dimethoxy-2,3-Dibromobenzene provide opportunities for sequential or multiple functionalization strategies.

Potential research areas include:

• Palladium-catalyzed cross-coupling
• Suzuki-type coupling research
• Stille-type coupling research
• C–C bond formation
• Construction of functional aromatic molecules

👉 Its dibromo structure offers researchers multiple positions for controlled molecular diversification.

🧪 Pharmaceutical & Medicinal Chemistry Research

Functionalized brominated aromatics are commonly used as intermediates in medicinal chemistry and pharmaceutical research because halogenated aromatic scaffolds can be further modified to generate structurally diverse molecules.

Potential applications include:

• Pharmaceutical intermediate research
• Medicinal chemistry
• Bioactive molecule synthesis
• Structure optimization
• Chemical library development

👉 Provides a useful aromatic building block for research programs involving multi-step synthesis and molecular optimization.

🖥️ Electronic & Advanced Material Research

Highly functionalized aromatic compounds are important starting materials for developing sophisticated molecular structures used in advanced material research. 1,4-Dimethoxy-2,3-Dibromobenzene can provide a functional aromatic core for constructing more complex molecules with tailored electronic and structural characteristics.

Research areas include:

• Functional organic materials
• Conjugated molecule synthesis
• Organic electronic material research
• Molecular engineering
• Advanced aromatic material development

👉 Its combination of bromine reactivity and methoxy substitution makes it a useful precursor for functional aromatic material research.

🌟 Specialty Chemical Development

The precisely defined substitution pattern of 1,4-Dimethoxy-2,3-Dibromobenzene makes it suitable for specialty chemical projects requiring a well-characterized aromatic intermediate.

Potential applications include:

• Specialty chemical synthesis
• Functional molecule development
• Research chemicals
• Advanced intermediate development
• Custom synthesis projects

👉 A flexible building block for developing high-value aromatic compounds and specialty chemicals.

🧫 Academic & Laboratory Research Applications

1,4-Dimethoxy-2,3-Dibromobenzene is suitable for academic laboratories, research institutes, and industrial R&D teams studying aromatic chemistry and synthetic methodology.

Common research applications include:

• Organic chemistry studies
• Synthetic route development
• Cross-coupling reaction research
• Reaction mechanism studies
• Functional molecule design

Commercial sources identify the compound for scientific research and development applications.

⚙️ Chemical Reactivity and Functionalization

The chemical value of 1,4-Dimethoxy-2,3-Dibromobenzene is closely related to its combination of two aryl bromide groups and two methoxy groups.

The bromine atoms provide useful reaction sites for further functionalization, particularly in transition-metal-catalyzed coupling chemistry. This allows researchers to replace or transform the brominated positions and construct more complex aromatic architectures.

At the same time, the methoxy groups contribute to the electronic characteristics of the aromatic ring and help define the reactivity of the molecular scaffold.

This combination makes 1,4-Dimethoxy-2,3-Dibromobenzene a useful platform for developing structurally diverse aromatic intermediates and functional molecules.

📋 Product Information

Reported physical-property data include a molecular weight of approximately 295.96 g/mol, melting point of 154–158°C, and white to off-white solid appearance. Actual product specifications should be confirmed against the applicable batch COA.

📦 Packaging & Storage

1,4-Dimethoxy-2,3-Dibromobenzene should be stored in a properly sealed container under suitable conditions to maintain product quality.

• Store in a cool, dry, and well-ventilated place
• Keep the container tightly closed
• Protect from moisture and direct sunlight
• Avoid unnecessary exposure to heat and contamination
• Follow the product SDS for detailed handling and safety requirements

Commercial product information also recommends storage in a sealed, dry environment at room temperature, while some suppliers recommend additional protection from light and moisture.

🌍 Growing Demand in Advanced Chemical Research

The continued development of functional organic molecules, advanced aromatic materials, and increasingly sophisticated synthetic methodologies is driving interest in precisely functionalized aromatic intermediates.

1,4-Dimethoxy-2,3-Dibromobenzene (CAS 5030-61-5) offers researchers a compact and highly functionalized aromatic platform combining two reactive bromine sites with two methoxy substituents. This structural versatility makes it suitable for research involving organic synthesis, molecular functionalization, specialty chemicals, and advanced materials.

We provide reliable supply solutions for 1,4-Dimethoxy-2,3-Dibromobenzene, supported by quality control and technical documentation such as COA, SDS, and TDS. Custom specifications, packaging, and synthesis support can also be discussed according to project requirements.