1. 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one； CAS: 27387-31-1 is Ondansetron EP Impurity C and intermediate.
2. Product Overview
1,2,3,4-Tetrahydro-9-methylcarbazol-4-one is Key starting intermediate for Ondansetron Hydrochloride (antiemetic API).
3. Basic Product Information
Product Name: 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one
Synonyms: 1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOL-4-ONE;9-METHYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-4-ONE; Anthrdancione intermediate;Ondansetron EP Impurity C
CAS: 27387-31-1
MF: C13H13NO
MW: 199.25
EINECS: 608-096-1
Structural formula:
Purity: 99%
Product Categories: Aromatics;Heterocycles;Impurities;Intermediates
Melting point: 199.0 to 203.0 °C
Boiling point: 383.5±11.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
Solubility: Chloroform (Slightly), Methanol (Slightly, Heated, Sonicated)
Appearance: White Needlelike crystalline powder
HS code: 2933990099
Transport Information: Non-hazardous goods
COA:Cas no 27387-31-1 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one COA
Product Manager Email:crystal@coreychem.com
4. Frequently Asked Questions (FAQ)
1. What is the main purpose of 1,2,3,4-Tetrahydro-9-methylcarbazol-4-one?
It is a critical starting intermediate for ondansetron hydrochloride API. Ondansetron hydrochloride, a highly selective 5-HT₃ receptor antagonist, is a widely used antiemetic for chemotherapy-, radiotherapy- and surgery-triggered nausea and vomiting.
2. What are the key physical or chemical properties?
The compound is stable with low hygroscopicity. Strong light will induce yellow discoloration over time and reduce HPLC purity.
3. Annual production capacity, batch production capacity, purity standard?
Our product has 99% purity with minimal batch-to-batch variation. All known and unknown impurities are strictly controlled for pharmaceutical use. Ton-scale batches are feasible, and we can schedule production quickly for large orders.
4. What are the downstream products?
Mannich Intermediate
• 3-(Dimethylaminomethyl)-1,2,3,9-tetrahydro-9-methylcarbazol-4-one (CAS:153139-56-1)
Synthesized via Mannich reaction of carbazolone, paraformaldehyde and dimethylamine hydrochloride. It reacts with 2-methylimidazole through amine exchange to produce ondansetron free base, the main intermediate in commercial manufacturing.
• 1,2,3,9-Tetrahydro-9-methyl-3-methylenecarbazol-4-one (CAS:99614-64-9)
A Mannich elimination product acting as both a key intermediate and process impurity in this synthetic route.
5. Can special requirements be met?
If you have any special requirements, such as higher purity, lower impurity standards, etc., we can make adjustments based on the actual production situation to meet your needs.
5. Application Cases
Core Applications: Key starting intermediate for Ondansetron Hydrochloride (antiemetic API) The Mannich reaction produces the dimethylaminomethylcarbazolone intermediate, which then undergoes amine exchange to synthesize ondansetron free base. Subsequent salt formation yields Ondansetron Hydrochloride.
Ondansetron Hydrochloride: a highly selective 5-HT₃ receptor antagonist, clinically applied for nausea and vomiting induced by chemotherapy, radiotherapy and surgery. It is a mainstream antiemetic agent.
Second Major Application: Pharmaceutical impurity reference standard (Ondansetron EP Impurity C / USP Impurity C) As a calibrated impurity standard, it is used for related substance testing, method validation and quality control of ondansetron API and formulations. Pharmaceutical manufacturers, drug control institutes and third-party testing laboratories purchase this material as a standard for HPLC qualitative and quantitative analysis.
Other Minor Applications: New drug research and development: The carbazole parent skeleton is used in the synthesis and research of other 5-HT₃ receptor modulators and heterocyclic small-molecule drugs.
6. Safety and Storage
Packing size:
5kg/aluminium foil bag
25kg/Fiber can
Packing photo:
Storage temp：
Keep in dark place,Sealed in dry,Room Temperature
Expiration date：
About 36 months if properly stored
7. Contact us
Contact person:Crystal@coreychem.com
Website: www.coreychem.com
