1,2-Dioleoyloxy-3-(dimethylamino)propane/DODAP(CAS No.: 127512-29-2)
Product Manager: selina zhang; Email: selina@coreychem.com
- Appearacne: Colorless to light yellow oily liquid
- Solubility: Insoluble in water, soluble in DMSO, methanol, ethanol
- Purity: No less than 98%
- Storage: -20℃ ±5℃ protect from light, moisture and air
| Product Name | DODAP |
| Synonyms | 18:1DAP;9-Octadecenoicacid(9Z)-1,1′-[1-[(dimethylamino)methyl]-1,2-ethanediyl]ester;1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE;1,2-DIOLEOYL-3-DIMETHYLAMMONIUM-PROPANE;DODAP;(+/-)-N,N-dimethyl-N-[2,3-bis(9-(Z)-octadecanoyloxy)propyl]amine;1,2-dioleoyl-3-dimethylammonium-propane(DODAP);(Z)-3-(Dimethylamino)propane-1,2-diyldioleate |
| CAS NO | 127512-29-2 |
| Purity | 98% |
| Appearance | Colorless to light yellow oily liquid |
| MF | C41H77NO4 |
| MW | 648.05 |
| Contact | selina@coreychem.com |
DODAP (CAS: 127512‑29‑2, full name 1,2-dioleoyl-3-dimethylammonium-propane) is a cationic lipid widely used in biochemistry and drug delivery. Its main functions are:
-
Gene Delivery Carrier
-
DODAP can be used to prepare liposomes or nanoparticles for delivering DNA, siRNA, or mRNA into cells.
-
It forms cationic lipid–nucleic acid complexes (lipoplexes) by binding with negatively charged nucleic acids, protecting them and facilitating cellular uptake.
-
-
pH-Sensitive Lipid
-
DODAP is mostly neutral at physiological pH, reducing toxicity.
-
In acidic environments (such as endosomes), it becomes positively charged, helping disrupt the endosomal membrane and release nucleic acids into the cytoplasm.
-
This property makes it highly useful in mRNA vaccines and gene therapy.
-
-
Drug Delivery Aid
-
DODAP can be combined with other lipids (e.g., DSPC, cholesterol, PEG-lipid) to form stable lipid nanoparticles (LNPs) for delivering small molecule drugs or nucleic acid therapeutics.
-
In short, DODAP primarily acts as a cationic lipid carrier for nucleic acids, widely applied in gene therapy, mRNA vaccines, and lipid nanoparticle-based drug delivery.
Other related product recommendations：
- CAS:1796596-37-6; 4-((Fluorosulfonyl)oxy)benzoic acid
- CAS:1796596-42-3; 3-((fluorosulfonyl)oxy)benzoic acid
- CAS: 2179072-33-2; 1-(Fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate
- CAS: 326495-23-2; 1-stearoyl-2-hydroxy-sn-glycero-3-phospho-(1′-rac-glycerol) (sodium salt)
- CAS: 1217306-46-1; DLin-K-C3-DMA
- CAS: 1360858-99-6; DSPE-Maleimide
- CAS: 832-97-3; DL-Indole-3-lactic acid
- CAS: 1857341-90-2; 1,19-bis[2-[2-methyl-3-(octylthio)-1-oxopropoxy]ethyl] ester
- CAS: 2107505-65-5; ethyl 5-chloro-1H-pyrrole-3-carboxylate
- CAS: 37964-17-3; Ethyl 1H-pyrrole-3-carboxylate
- CAS: 1207557-35-4; Ethyl 6-Bromo-4-Methoxypyrazolo[1,5-A]pyridine-3-carboxylate
- CAS: 69525-80-0; 1-tetradecanoyl-2-hexadecanoyl-sn-glycero-3-phosphocholine
We are also skilled in providing customized synthesis and corresponding scale-up services.
Please feel free to contact us for any related product or service needs: selina@coreychem.com
