📰10-Chloro-1-decanol (CAS 51309-10-5): A Long-Chain Chloro Alcohol Building Block for Organic Synthesis and Functional Materials

September 4, 2026

1、Product Overview

10-Chloro-1-decanol, also known as 10-chlorodecan-1-ol or 1-decanol, 10-chloro-, is a bifunctional aliphatic building block containing both a terminal hydroxyl group (-OH) and a terminal chlorine atom (-Cl) within a linear ten-carbon chain.

Its molecular structure can be represented as Cl(CH₂)₁₀OH. The combination of a primary alcohol and an alkyl chloride gives 10-Chloro-1-decanol useful chemical reactivity, allowing it to participate in different types of functionalization reactions, including nucleophilic substitution and esterification.

Because the two functional groups are located at opposite ends of a relatively long hydrocarbon chain, 10-Chloro-1-decanol can serve as a useful C10 bifunctional synthon for constructing more complex organic molecules. It has been described as a building block for organic synthesis and pharmaceutical chemistry, while its long hydrophobic chain also makes it of interest in certain material and specialty-chemical research areas.

The compound is commercially available in research and industrial chemical markets, with reported assay specifications including 97% and higher-purity grades depending on the supplier and application.

2、Basic Product Information

1）Product Name: 10-Chloro-1-decanol

2）CAS NO.: 51309-10-5

3）Molecular Formula: C₁₀H₂₁ClO

4）Molecular Weight: 192.73 g/mol

5）Structural Formula: 

6）Purity: ≥97%

7）Appearance: Colorless to pale-yellow liquid

8）Melting Point: 12–13 °C

9）Boiling Point: 126–128 °C at 2 mmHg

10）Density: Approximately 0.952 g/mL at 25 °C

11）Refractive Index: n²⁰/D approximately 1.46

12）Product Manager Email:Echo@coreychem.com

3、Frequently Asked Questions (FAQ)

1）Is 10-Chloro-1-decanol a liquid at room temperature?

It depends on the ambient temperature. 10-Chloro-1-decanol has a melting point of around 12–13 °C, so it is generally a liquid at normal room temperature but may become solid or semi-solid under cooler conditions. This should be considered when sampling, transferring or handling the material.

2）What types of chemical reactions can 10-Chloro-1-decanol undergo?

The terminal alcohol can participate in reactions such as esterification, ether formation and oxidation, while the terminal chlorine can potentially undergo nucleophilic substitution.

This combination provides flexibility for sequential or selective functionalization and allows the C10 chain to be incorporated into more complex molecular architectures.

3）Is 10-Chloro-1-decanol mainly used as a final product or an intermediate?

It is primarily regarded as a research and synthesis building block rather than a finished active ingredient.

Commercial chemical suppliers commonly position it as an organic synthesis intermediate or building block, including applications related to pharmaceutical chemistry and other advanced chemical research.

4）Why is the long C10 carbon chain important?

The ten-carbon linear chain provides a relatively large hydrophobic segment while retaining reactive functional groups at the terminal positions.

This combination can be valuable in molecular design where researchers need to introduce both a long alkyl spacer and chemically addressable terminal groups. It can therefore be considered for organic synthesis, specialty molecules and selected material-related research.

5）Can 10-Chloro-1-decanol be used for further chemical modification?

Yes. The molecule contains two different terminal functional groups: a primary hydroxyl group and a chlorine atom. The hydroxyl group can be used for esterification, etherification or other transformations, while the chloroalkyl end can participate in substitution reactions. This makes it suitable as an intermediate for multi-step synthesis.

4、Application Cases

1）Organic Synthesis: Construction of Functionalized C10 Building Blocks

It can be used as a bifunctional intermediate for constructing molecules that require a long-chain alkyl segment together with differentiated terminal functionality.

The primary alcohol can be converted into esters, ethers or other oxygen-containing derivatives, while the terminal chloride provides another reaction site for subsequent substitution chemistry. This makes the compound useful for multi-step organic synthesis.

2）Pharmaceutical and Medicinal Chemistry Research

It has been commercially identified as a building block relevant to pharmaceutical chemistry and inhibitor-related synthesis.

In medicinal chemistry, bifunctional building blocks are often valuable for modifying molecular structures, introducing flexible alkyl linkers, or preparing downstream intermediates for structure-activity relationship studies.

Its C10 chain and two terminal functional handles provide a convenient starting point for such synthetic exploration.

3）Synthesis of Long-Chain Esters and Ethers

The hydroxyl group of 10-Chloro-1-decanol can undergo esterification or ether-forming reactions, allowing researchers to prepare derivatives containing a long hydrophobic chain.

Such derivatives can be investigated in areas including specialty organic chemicals, surfactant-related chemistry and functional molecular design, depending on the structure of the downstream product.

4）Preparation of Functional Materials and Specialty Chemicals

The combination of a hydrophobic C10 chain with a reactive terminal chlorine and alcohol functionality provides opportunities for molecular modification in material science and specialty-chemical research.

For example, functionalized derivatives can be designed to alter hydrophobicity, intermolecular interactions or reactivity when incorporated into more complex molecular structures. Commercial chemical references specifically identify potential applications in specialty polymers and surfactant-related research.

5）Proteomics and Research-Chemical Applications

It is also commercially described as a chlorinated long-chain primary alcohol compound for proteomics research.

In research environments, compounds of this type can serve as specialized chemical building blocks or experimental reagents. Its defined molecular structure and terminal functional groups make it suitable for research involving chemical modification and synthesis.

5、Safety and Storage

1）Keep the container tightly closed when not in use.

2）Store in a cool, dry and well-ventilated area, away from incompatible substances.

3）Because the reported melting point is approximately 12–13 °C, temperature should be considered during storage and handling.

4）Avoid unnecessary exposure to heat, moisture and direct sunlight.