| Product name | 1-(Perfluorobut-1-yl)pentane |
| Synonym | 1-(Perfluorobutyl)pentane, 1,1,1,2,2,3,3,4,4-Nonafluorononane, |
| CAS NO. | 1190430-21-7 |
| Appearance | Colorless transparent liquid |
| Purity | 99% Min |
| MF | C₉H₁₁F₉ |
| MW | 290.17 |
| Density | 1.282±0.06 g/cm³ |
| Boiling Point | 152.1±8.0 ℃ at 760 mmHg |
| Water Solubility | Immiscible or poorly soluble |
| Vapor Pressure | 25.1 mmHg at 37℃ |
| Storage Condition | Store in a cool, dry, well-ventilated place away from light, ignition sources, and heat. Keep container tightly sealed. |
| Package | 500g plastic drum, 5kg plastic drum, 25kg & 50kg steel-plastic composite drum. Customizable packaging is available upon request. |
| Structural formula |  |
| Related categories | Fluorinated compound, Specialty chemical, Pharmaceutical intermediate |
| Transport Information | Conventional chemical transport regulations apply. |
| HS Code | 2903499090 |
| Product Manager Email |
Key Applications and Uses:
1. Ophthalmic Drug Delivery – A Novel Eye Drop Excipient
1-(Perfluorobutyl)pentane serves as an advanced pharmaceutical excipient in ophthalmology, capable of effectively dissolving various poorly water-soluble active pharmaceutical ingredients (APIs). It is utilized in the development of treatments for conditions such as:
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Dry eye syndrome
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Glaucoma
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Corneal infections
A notable example is its use in Cyclosporine eye drops, a first-line treatment for moderate to severe dry eye. The compound can directly dissolve cyclosporine to form a clear, transparent solution, which not only enhances drug bioavailability and prolongs therapeutic action but also inhibits microbial growth and reduces the incidence of adverse reactions.
2. Ophthalmic Surgical Applications
With a long history of use in eye surgery, 1-(Perfluorobutyl)pentane functions as an effective silicone oil remover during vitreoretinal procedures. It helps clear residual silicone oil from the eye, minimizing issues such as oil emulsification and the formation of “sticky silicone oil” when in contact with perfluorocarbon liquids.
3. Topical Dermatological Use
Currently under clinical investigation, this compound is being studied for its potential in topical skin applications, leveraging its stability and biocompatibility for localized treatment formulations.
4. Medical Imaging and Diagnostics
It is also employed in medical imaging, particularly as a component in ultrasound contrast agents, enhancing imaging clarity and diagnostic accuracy.
5. Industrial and Cosmetic Formulations
Beyond healthcare, 1-(Perfluorobutyl)pentane finds utility in:
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Cosmetic formulations as a solvent or dispersing medium
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High-end electronic materials where its chemical stability and solubility properties are advantageous
Future Outlook
As a semi-fluorinated alkane with excellent safety and tolerability profiles, 1-(Perfluorobutyl)pentane holds significant promise in expanding the possibilities for drug delivery and formulation—particularly in ophthalmology and beyond. Its ability to act as a versatile carrier for oxygen and proteins further supports its potential in developing next-generation biopharmaceutical suspensions and therapeutic systems.
Contact information:
Contact: Sophia Li
Email: sophia@coreychem.com
