Category Info of Pyrrolopyrazines:
Nitrogen-containing heterocyclic compounds have a wide range of applications in medicine, organic materials, natural products and other fields, mainly for biologically active molecules. Pyrrolopyrazines contain pyrrole and pyrazine rings as bioactive scaffolds.Compounds containing this scaffold have a wide range of biological activities, such as antibacterial, anti-inflammatory, antiviral, antifungal, antioxidant, antitumor, and kinase inhibition.
Overview:
1-Chloro-3-methylpyrrolo[1,2-a]pyrazine is a heterocyclic compound characterized by a fused pyrrole and pyrazine ring system with a chlorine atom and a methyl group at specific positions. Its molecular formula is C8H7ClN2,and it has a molecular weight of approximately 166.61 g/mol.The compound is notable for its structural features, which contribute to its unique chemical properties and biological activities.
Chemical Properties:
Stability: Generally stable under standard laboratory conditions but may decompose under extreme pH or temperature; Reactivity: Exhibits reactivity typical of chlorinated heterocycles, particularly in nucleophilic substitution reactions.
Biological Activity: 1-Chloro-3-methylpyrrolo[1,2-a]pyrazine exhibits various biological activities, particularly in pharmacological contexts. Compounds in this class have shown potential as: Antimicrobial agents: They may inhibit the growth of bacteria and fungi. Antitumor activity: Some derivatives have been linked to reduced tumor growth in preclinical models. Kinase inhibition: Certain pyrrolopyrazines have demonstrated activity against specific kinases, making them candidates for cancer therapy
Reactions:
Substitution Reactions: The chlorine atom can be substituted by various nucleophiles such as sodium methoxide or potassium tert-butoxide, leading to the formation of derivatives like 1-methoxy-3-methylpyrrolo[1,2-a]pyrazine.
Oxidation and Reduction: The compound can be oxidized to form N-oxides or reduced to yield amines, demonstrating its versatility in synthetic organic chemistry.
Cyclization Reactions: It can participate in further cyclization reactions to create more complex heterocyclic structures.
Applications: 1-Chloro-3-methylpyrrolo[1,2-a]pyrazine has several significant applications across various scientific fields: -Chemistry: Serves as a building block for synthesizing more complex heterocyclic compounds. -Biology: Utilized in studies investigating biological pathways due to its unique structural properties. -Medicine: Ongoing research explores its potential as a pharmacophore in drug discovery, particularly for antimicrobial and anticancer applications. -Industry: Employed in developing new materials and as an intermediate in synthesizing various chemical products
Product manager: Joy Wu Contact/Email address: Joy@coreychem.com
