Product Specifications
| Item | Detail |
|---|---|
| Product Name | 1-Bromo-3,5-difluorobenzene-d3 |
| CAS Number | 1219798-73-8 |
| Molecular Formula | C₆H₃BrF₂ |
| Molecular Weight | 192.99 |
| Appearance | Colorless to pale yellow transparent liquid |
| Boiling Point | 140.0 °C (760 mmHg) |
| Density | 1.7 ± 0.1 g/cm³ |
| Flash Point | 44.4 °C |
| Purity | ≥ 98% (COA and NMR spectra available) |
Applications
Why Deuterated Compounds Matter
Deuterium (²H or D), a stable, non-radioactive isotope of hydrogen, has become the gold-standard labeling element in modern pharmaceutical research. Its nearly identical chemical behavior to hydrogen — combined with a distinct mass detectable by mass spectrometry — makes deuterated internal standards (SIL-IS) indispensable tools for quantitative bioanalysis using LC-MS/MS. By compensating for matrix effects and ionization variability, deuterated internal standards enable highly accurate, reproducible pharmacokinetic data.
Key Applications
1. Drug Metabolism & Pharmacokinetics (DMPK) As a versatile deuterated building block, 1-Bromo-3,5-difluorobenzene-d3 serves as a key precursor for synthesizing deuterium-labeled drug candidates, metabolites, and reference standards. It is widely employed in preclinical and clinical DMPK studies, bioavailability and bioequivalence (BA/BE) assessments, and drug-drug interaction (DDI) investigations.
2. Bioanalytical Method Development Stable isotope-labeled internal standards derived from this compound significantly enhance the linear range, precision, and accuracy of LC-MS/MS methods — making it an essential tool for bioanalytical laboratories worldwide.
3. Organic Optoelectronic Materials The fluorinated aromatic scaffold of 1-Bromo-3,5-difluorobenzene is widely utilized in OLED and advanced optoelectronic material design. The bromine substitution site provides flexible derivatization opportunities, while deuterium labeling offers a unique approach to investigating material degradation mechanisms and lifetime performance.
4. Pharmaceutical Intermediates & Custom Synthesis As a fluorinated, deuterated pharmaceutical intermediate, this compound is well-suited for structural modifications in SAR (Structure-Activity Relationship) studies. We also offer custom synthesis services using this product as a starting material, with flexible delivery from milligram to kilogram scale.
Product advantages
This product is manufactured via an independently developed synthetic route that has undergone multiple rounds of process optimization to ensure excellent batch-to-batch reproducibility. Every lot is rigorously tested by HPLC, GC, NMR, and MS, and accompanied by a full Certificate of Analysis (COA) and relevant spectra — guaranteeing traceable quality from R&D to scale-up production.
📦 Sample Requests Now Open Complimentary small samples are available for evaluation, along with COA and analytical data.
For custom deuterated compound synthesis or scale-up inquiries, please do not hesitate to reach out.
More details, just contact: Nicole@coreychem.com
